After Mystery Inc. accidentally caught an innocent man in a case, the squad has to hang up its detective work until further notice. But shortly thereafter an old friend, Vincent Van Ghoul, asks for their help and the team resumes its work. It all began with an earlier hunt for the 12 most feared ghosts in the world, but Scooby-Doo, Shaggy and Daphne did not succeed in catching the meanest of all ghosts at that time: the 13th ghost. This ghost is now haunting the world and the friends have to leave their unsolved secrets behind and settle a score. In this terribly entertaining film, they travel to the icy slopes of the Himalayas, where hair-raising chases, fortune telling balls and eerie spells await them.